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Supplements: The supplement with the most data for treating insulin resistance and diabetes is alpha lipoic acid. Insulin resistance is also very common: about one-third of adults within the United States have insulin resistance or a related condition referred to as prediabetes. If I have Insulin Resistance, Does That Mean I've Diabetes? Type 2 diabetes is certainly one of the commonest medical problems within the United States. RA usually causes joints to be affected bilaterally